Liver Tumours – Good & Evil is Decided by Two Signalling Pathways - The linking of two signalling pathways in the cells of liver tumours has a clear influence on their malignancy. Activation of the platelet-derived growth factor (PDGF) messenger molecule is decisive for this linking. This results related to the development of liver cancer was generated during a current project by the Austrian Science Fund FWF and has been published in the Journal Oncogene. When the signalling pathways in liver tumour cells have been linked together, these cells develop the characteristics of cancer stem cells, which are in principal resistant to chemotherapy. This new understanding of the signalling pathways involved unlocks potential for the future development of modified therapies.
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